Clinical study on the risk of sarcopenia in patients with advanced lung cancer undergoing anti-tumor therapy
10.3969/j.issn.1671-8348.2024.09.013
- VernacularTitle:晚期肺癌抗肿瘤治疗患者并发肌少症风险的临床研究
- Author:
Xiaozhen LUO
1
;
Lingling XIE
;
Xiaozhen LEI
;
Lili YANG
;
Xin YANG
;
Yan LIAO
Author Information
1. 成都上锦南府医院/四川大学华西医院上锦医院肿瘤一科,成都 611730
- Keywords:
sarcopenia;
advanced lung cancer;
related factors;
quality of life
- From:
Chongqing Medicine
2024;53(9):1348-1352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors of sarcopenia in patients with advanced lung cancer undergoing anti-tumor therapy,and to explore the adverse effects of sarcopenia on patients with ad-vanced lung cancer undergoing anti-tumor therapy.Methods Patients with advanced lung cancer who received anti-tumor therapy in the Department of Oncology of a tertiary hospital in Chengdu from January to December 2021 were continuously included.The incidence situation of sarcopenia in patients with advanced lung cancer undergoing anti-tumor therapy was evaluated by using the 12th thoracic spine (T12) skeletal muscle index (SMI) standard.According to the diagnostic criteria of sarcopenia,the patients were divided into the sarcope-nia group and the non-sarcopenia group.Multivariate logistic regression was used to analyze the influencing factors of sarcopenia in patients with advanced lung cancer undergoing anti-tumor therapy.Results A total of 285 patients were included in this study,of which 123 cases (43.15％) were diagnosed as sarcopenia.Multiva-riate analysis showed that gender (P<0.001),pathological stage (P=0.012),creatinine (P=0.031) and BMI (P<0.001) were the influencing factors of sarcopenia in patients with advanced lung cancer undergoing anti-tumor therapy.The quality of life score of patients in the sarcopenia group was significantly lower than that in the non-sarcopenia group (P=0.035).Conclusion The incidence of sarcopenia in patients with ad-vanced lung cancer undergoing anti-tumor therapy is high,which is related to many factors and affects the quality of life.
