Expression and significance of MMR protein,HER2 and Ki-67 in colorectal cancer
10.3969/j.issn.1671-8348.2024.09.007
- VernacularTitle:MMR蛋白、HER2、Ki-67在结直肠癌中的表达及意义
- Author:
Fei YANG
1
;
Yaming ZHANG
;
Chaoping ZHOU
;
Datian WANG
;
Bin GAO
;
Jun MA
;
Daibin TANG
;
Jianwei YUAN
;
Yuxiang WANG
Author Information
1. 安庆市立医院普外科,安徽安庆 246000
- Keywords:
colorectal neoplasms;
mismatch repair protein;
human epidermal growth factor receptor 2;
Ki-67;
immunohistochemistry
- From:
Chongqing Medicine
2024;53(9):1317-1322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of mismatch repair (MMR) protein,human epidermal growth factor receptor (HER)2 and Ki-67 in colorectal cancer.Methods The clini-cal data of 559 patients with colorectal cancer who underwent surgical treatment in the hospital from October 2017 to May 2022 were retrospectively analyzed.The expressions of MMR protein (MLH1,MSH2,PMS2, MSH6),HER2 and Ki-67 in colorectal cancer were detected by immunohistochemistry,and the relationship between them and the clinicopathological features of colorectal cancer was analyzed.Results Among the 559 patients with colorectal cancer,43 cases (7.7％) were deficient mismatch repair (dMMR),8 cases(1.4％) were HER2 +++,and 251 cases (44.9％) were Ki-67 +++.The expression rate of dMMR in the colorec-tal cancer patients with different age,tumor location,tumor maximum diameter,gross type,histological grade,lymph node metastasis and TNM stage was significantly different (P<0.05).The expression rate of HER2 ++/+++ in the patients with different gross types of colorectal cancer was statistically significant (P<0.05).The expression rate of Ki-67 +++ in the colorectal cancer patients with different histological types,histological grades,lymph node metastasis,distant metastasis and TNM staging was statistically signifi-cant (P<0.05).There was no correlation between MMR protein and the expression of HER2 and Ki-67 (P>0.05).Conclusion The expression of MMR proteins in colorectal cancer is closely related to its clinicopatho-logical features.
