Analysis on causal relationship between rheumatoid arthritis and its serological antibodies levels with pre-eclampsia based on Mendelian randomization
10.3969/j.issn.1671-8348.2024.09.002
- VernacularTitle:基于孟德尔随机化的类风湿性关节炎及其血清抗体水平与子痫前期的因果关系分析
- Author:
Jiayan MIAO
1
;
Yating QIAN
;
Yixiao WANG
;
Xuan XUE
Author Information
1. 南京医科大学附属妇产医院/南京市妇幼保健院妇产科,南京 210004
- Keywords:
rheumatoid arthritis;
serological antibodies;
pre-eclampsia;
Mendelian randomization;
causal relationship
- From:
Chongqing Medicine
2024;53(9):1289-1294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic causal relationship between rheumatoid arthritis (RA) and its serological antibody levels with pre-eclampsia (PE) based on Mendelian randomization (MR). Methods Single nucleotide polymorphism (SNP) with significant differences were screened as instrumental variables,and the five MR analytic method with the inverse variance weighting (IVW) as the main analytical method were applied to comprehensively assess the causal cc relationship between OA,serum antibody levels PE.The MR-Egger intercept method,MR pleiotropy residual and outlier (MR-PRESSO) method,Cochrane's Q-test were applied to explore the horizontal pleiotropy and heterogeneity of SNP,and the leave-one-out meth-od was used to explore the effect of individual SNPs on MR results.Results The IVW result indicated that RA (OR=1.098,95％CI:1.036-1.164,P=0.002) and seropositive RA (OR=1.088,95％CI:1.026-1.153,P=0.005) were the PE risk factors,whereas seronegative RA (OR=1.036,95％CI:0.971-1.104, P=0.282) did not have a significant causal relationship with PE.No significant level pleiotropy or heteroge-neity was found in the SNPs used in MR analyses of the 3 exposure factors.rs34434863 played a decisive role in the causal relationship of RA and seropositive RA with PE.Conclusion Based on MR analysis,there is a significant positive causal relationship between RA and seropositive RA with PE,whereas there was no signifi-cant causal relationship between seronegative RA and PE.
