Clinical research of calcium folinate rescue in high-dose methotrexate therapy at different times
10.3760/cma.j.issn.1674-2907.2011.15.003
- VernacularTitle:不同时间四氢叶酸钙解救大剂量甲氨蝶呤化疗毒副作用的研究
- Author:
Xiu-Ping ZHANG
1
;
Zhong-Li PEI
;
Mei ZHU
;
De-Hua LIAN
Author Information
1. 山东省滕州市中心人民医院
- Keywords:
Calcium folinate;
Methotrexate;
Toxicity;
Rescue
- From:
Chinese Journal of Modern Nursing
2011;17(15):1745-1748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects of calcium folinate(CF)rescue on high-dose methotrexate (HDMTX)therapy at different times.Methods Children with acute lymphocytic leukemia(ALL)who met the inclusion criteria were randomly divided into two groups in line with chemotherapy order:observation group(Group A)and control group(Group B).Chemotherapy regimens included remission induction chemotherapy(VDLD),consolidation therapy(CAT),shelters to prevent(HDMTX+CF),reinduction therapy.Group A was intravenously injected HDMTX for 24 hours and then rescued by CF for 12hours.Group B was intravenously injected HDMTX for 6 hours and then rescued by CF for 30 hours.Side effects after administration of medicine were observed,in particular,the gastrointestinal tract reaction,which included nausea and vomiting,oral mucous membrane reaction,leukocyte reaction,the toxicity of the heart,liver,kidney,nerve and response durations.Results There were significant differences in both groups on response degree in the gastrointestinal tract reaction,oral mucous membrane reaction,and leukocyte reaction (P<0.01,P<0.05);while there was significant difference in response duration after chemotherapy for both groups(P<0.01).There was no significant difference in the heart,liver,kidney,neurological toxicity reaction(P>0.05).Conclusions There are differences in side effects of CF rescue on HDMTX therapy at different times.Both groups could reduce the toxic reaction,but the protocol that gives HDMTX for 24 hours and then rescues by CF for 12 hours is more conducive to repair the normal tissue cell's damage,improve chemotherapy efficacy and children's quality of life,with a better clinical value.
