Expression of CD99 in Pleomorphic Carcinomas of the Lung.
10.3346/jkms.2005.20.1.50
- Author:
Seong Ho YOO
1
;
Jungho HAN
;
Tae Jin KIM
;
Doo Hyun CHUNG
Author Information
1. Department of Pathology Seoul National University College of Medicine, Seoul, Korea. doohyun@plaza.snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Pleomorphic Carcinoma;
Lung Neoplasms;
CD99 Protein, Human
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antigens, CD/*biosynthesis;
Carcinoma/*metabolism;
Cell Adhesion Molecules/*biosynthesis;
Female;
Humans;
Immunohistochemistry;
Immunophenotyping;
Intermediate Filament Proteins/biosynthesis;
Keratin/biosynthesis;
Lung Neoplasms/*metabolism;
Male;
Middle Aged;
Nuclear Proteins/biosynthesis;
Prognosis;
Research Support, Non-U.S. Gov't;
Sarcoma/metabolism;
Time Factors;
Transcription Factors/biosynthesis
- From:Journal of Korean Medical Science
2005;20(1):50-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pleomorphic carcinoma of the lung (PCL) is characterized by a mixture of sarcomatoid and carcinoma components, and a poor prognosis. However, no immunophenotype of tumor markers has been characterized in PCL. To charaterize the immunophenotype for CD99 in PCL, we performed an immunohistochemical evaluation of PCLs for thyroid transcription factor-1 (TTF-1), cytokeratin (CK) 7 and 20, and for CD99. CD99 was found to be expressed in both carcinomatous (47%) and sarcomatous components such as spindle cells (92%) and giant cells (57%). In the case of spindle cells, CK7 was expressed in 6 cases (46%) and TTF-1 in 2 cases (15%), whereas for giant cells CK7 was expressed in 8 cases (57%) and TTF-1 in one case (7%). However, CK20 was not expressed in either the carcinomatous or sarcomatous components in any case. Thus, CD99 was found to be widely expressed in both sarcomatous and carcinoma component in PCL. A clinicopathological analysis showed no direct correlation between the expression of CD99 and the clinical indices (stage, survival rate, invasion) of PCL.
