Basic research and clinical application progress of CAR-NK cells
10.3760/cma.j.cn115356-20231008-00050
- VernacularTitle:CAR-NK细胞的基础研究及临床应用进展
- Author:
Lanyan WANG
1
;
Xiangning LUO
;
Yajie WANG
Author Information
1. 昆明理工大学医学院 云南省第一人民医院，昆明 650093
- Keywords:
Killer cells, natural;
Chimeric antigen receptor T cell;
Hematologic malignancies;
Immunotherapy
- From:
Journal of Leukemia & Lymphoma
2024;33(10):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer (NK) cells are a part of the innate immune system, providing the first line of defense against pathogens and cancer cells. NK cells have multiple ways to kill tumor cells and have a stronger anti-tumor effect than T cells. NK cells-based adoptive cell immunotherapy has gradually shown its great advantages in the treatment of hematologic malignancies. This paper reviews the physiology of NK cells, the mechanism of chimeric antigen receptor (CAR)-NK cells, and the current clinical application of CAR-NK cells.
