Progress of gene mutations and myeloproliferative neoplasms

VernacularTitle:基因突变与骨髓增殖性肿瘤的研究进展
Author: Jian GAO ¹ ; Yu CHEN ; Yunfan YANG ; Ling PAN
Author Information

1. 四川大学华西医院血液科，成都　610041
Keywords: Myeloproliferative disorders; Mutation; Gene; Prognosis
From: Journal of Leukemia & Lymphoma 2024;33(9):565-568
CountryChina
Language:Chinese
Abstract: BCR-ABL1 fusion gene negative chronic myeloproliferative neoplasms (MPN) are a group of malignant disorders that originate from a single hematopoietic stem cells. There are a variety of gene mutations in the blood cells of MPN patients, including "disease driver gene mutation", "clone driver gene mutation" and "passenger gene mutation", which play an important role in the development and progression of MPN, and affect the treatment response and outcome of MPN patients. These gene mutations have been included in the MPN international prognostic scoring system. It is of great significance for the diagnosis and treatment of MPN.