Progress of mechanisms of erythroid abnormal amplification in polycythemia vera
10.3760/cma.j.cn115356-20230105-00004
- VernacularTitle:真性红细胞增多症红系异常扩增机制的研究进展
- Author:
Yanni CUI
1
;
Yan REN
;
Hongwei WANG
Author Information
1. 山西医科大学第二医院血液病分子诊疗重点实验室，太原 030001
- Keywords:
Polycythemia vera;
JAK2 V617F gene mutation;
Molecular biology
- From:
Journal of Leukemia & Lymphoma
2024;33(7):445-448
- CountryChina
- Language:Chinese
-
Abstract:
Polycythemia vera (PV) is a chronic clonal myeloproliferative disorder involving hematopoietic stem cells. This article provides a brief review of the mechanisms of erythroid abnormal amplification in PV, including the effects of JAK2 V617F and JAK2 Ex12 mutations on erythropoiesis and abnormal changes in non-specific regulation.
