Progress of metabolic reprogramming in chronic lymphocytic leukemia
10.3760/cma.j.cn115356-20230322-00069
- VernacularTitle:代谢重编程在慢性淋巴细胞白血病中的研究进展
- Author:
Xiaoling ZUO
1
;
Jianyong LI
;
Zijuan WU
Author Information
1. 南京医科大学第一附属医院血液科，南京 210029
- Keywords:
Leukemia, lymphocytic, chronic;
Metabolism;
Metabolic reprogramming
- From:
Journal of Leukemia & Lymphoma
2024;33(7):441-445
- CountryChina
- Language:Chinese
-
Abstract:
Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by clonal proliferation of lymphocytes. To meet the demands of energy, tumor cells can drive metabolic reprogramming. Previous studies have shown that the transformation of metabolic patterns in CLL cells is closely related to disease progression, treatment and prognosis. This article reviews the role of metabolic reprogramming in CLL in order to help in-depth understanding of the metabolic heterogeneity of CLL cells, and provide ideas for finding feasible therapeutic targets involved in the metabolic process of CLL.
