Progress of PI3K-AKT-mTOR signaling pathway in acute myeloid leukemia
10.3760/cma.j.cn115356-20220525-00150
- VernacularTitle:PI3K-AKT-mTOR信号通路在急性髓系白血病中的研究进展
- Author:
Pan ZHAO
1
;
Yajiao LI
;
Luwei YAN
;
Xuemei DONG
Author Information
1. 甘肃省妇幼保健院临床检验中心，兰州 730050
- Keywords:
Leukemia, myeloid, acute;
PI3K-AKT-mTOR;
Molecular targeted therapy
- From:
Journal of Leukemia & Lymphoma
2024;33(5):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Acute myelogenous leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of hematopoietic stem cells, and its morbidity and mortality are increasing, which seriously threatens human health. In recent years, many studies have shown that PI3K-AKT-mTOR signaling pathway is involved in the management of various biological processes in cells, and its abnormal activation is closely related to the occurrence and development of tumors. Therefore, this article reviews the recent research progress of PI3K-AKT-mTOR signaling pathway in the pathogenesis, progression and treatment of AML.
