Progress of selenium and its compounds in leukemia
10.3760/cma.j.cn115356-20230614-00131
- VernacularTitle:硒及其化合物在白血病中的研究进展
- Author:
Shuwen ZHANG
1
;
Ruifang ZHU
;
Hongwei WANG
Author Information
1. 山西医科大学医学科学院，太原 030001
- Keywords:
Selenium;
Leukemia;
Selenoprotein;
Trace element
- From:
Journal of Leukemia & Lymphoma
2024;33(5):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Selenium is one of the essential trace elements in human body, which plays an important role in regulating human growth and physiological function. Selenium deficiency can lead to a variety of diseases, such as Kashin-Beck disease, Keshan disease, thyroid disease and increase the incidence of cancer. It was found that serum selenium level decreased significantly in patients with leukemia, and it was associated with poor prognosis. Selenium can play a dual role in the treatment of leukemia: on the one hand, it can play a synergistic anti-leukemia effect with chemotherapy drugs, and on the other hand, it can reduce the side effects of chemotherapy drugs. In recent years, nano-selenium, as a new type of elemental selenium, has higher bioavailability, stronger bioactivity and lower toxicity than organic and inorganic selenium. This article reviews the progress of selenium and its compounds in leukemia.
