Posterior reversible encephalopathy syndrome after allogeneic hematopoietic stem cell transplantation: report of 1 case and review of literature
10.3760/cma.j.cn115356-20230828-00027
- VernacularTitle:异基因造血干细胞移植后可逆性后部白质脑病综合征1例并文献复习
- Author:
Lou GENG
1
;
Yang WANG
;
Xu XU
;
Jing SHENG
;
Jie CHEN
Author Information
1. 海军军医大学长海医院血液内科，上海 200433
- Keywords:
Hematopoietic stem cell transplantation;
Posterior reversible encephalopathy syndrome;
Epilepsy;
Diagnosis;
Treatment outcome
- From:
Journal of Leukemia & Lymphoma
2024;33(5):283-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To advance the understanding of posterior reversible encephalopathy syndrome (PRES) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods:The medical history, diagnosis and treatment process, laboratory examination and imaging examination results of a patient who developed PRES after undergoing allo-HSCT at Changhai Hospital of Naval Medical University in November 2022 were retrospectively analyzed, and the relevant literature was reviewed.Results:The patient was a 33-year-old woman, and she was admitted to the hospital with 17 years of diagnosis of aplastic anemia, 1 month after sibling-matched allo-HSCT, with low-grade fever for 1 week. On the 7th day of hospitalization, the patient experienced a sudden onset of seizures. After combining findings from cranial magnetic resonance imaging (MRI) and other relevant examinations, organic brain lesions were ruled out, and PRES was considered. The patient's condition improved after receiving antihypertensive, antiepileptic, anti-infection, and other appropriate treatments. A follow-up cranial enhanced MRI was performed 3 months after the onset of symptoms revealed the disappearance of lesions.Conclusions:PRES after allo-HSCT has the potential to yield favorable outcomes when it is promptly diagnosed and treated.
