Research progress in biological characteristics of dental pulp stem cells and their applications in treatment of corneal and retinal diseases
10.13481/j.1671-587X.20240633
- VernacularTitle:牙髓干细胞的生物学特性及其在角膜和视网膜疾病治疗中应用的研究进展
- Author:
Xiangyu LIU
1
;
Mengdi ZHANG
;
Jixue WANG
;
Chunling XU
Author Information
1. 吉林大学第二医院眼科,吉林 长春 130041
- Keywords:
Dental pulp stem cells;
Eye;
Cornea;
Retina;
Paracrine
- From:
Journal of Jilin University(Medicine Edition)
2024;50(6):1773-1779
- CountryChina
- Language:Chinese
-
Abstract:
Dental pulp stem cells(DPSCs)are a type of mesenchymal stem cells with broad application potential.Due to their multipotent differentiation capabilities and ease of access,DPSCs have become a focus of research in the field of ophthalmology.In recent years,DPSCs have shown the potential clinical applications in the treatment of corneal epithelial injuries and retinal degenerative diseases.DPSCs can promote the corneal epithelial regeneration and reconstruction by differentiating into the corneal epithelial cells and inhibiting the M1 macrophages.Additionally,DPSCs can differentiate into the retinal photoreceptor-like cells and retinal ganglion-like cells,replace original retinal neurons,secrete neurotrophic factors to mediate injury repair,promote retinal regeneration,and improve the original function of the retina.This article systematically reviews the relevant domestic and international literatures in recent years,discussing the biological characteristics of DPSCs and the research progress in their applieation in the treatment of corneal and retinal diseases,with the aim of providing insights and strategies for the study of DPSCs in translational medicine and ophthalmic-related diseases.
