Research progress in changes of intestinal flora after spinal cord injury and their effects on spinal neuroinflammation
10.13481/j.1671-587X.20240630
- VernacularTitle:脊髓损伤后肠道菌群变化及其对脊髓神经炎症影响的研究进展
- Author:
Haixia CHEN
1
;
Hongru LI
;
Jingyi LIU
;
Zhifang XU
;
Shuwen LIU
;
Yuan YANG
;
Yang CHEN
;
Yu LUO
;
Yinjie CUI
Author Information
1. 天津中医药大学针灸推拿学院 实验针灸学研究中心,天津 301617
- Keywords:
Spinal cord injury;
Spinal neuroinflammation;
Gut microbiota;
Metabolism
- From:
Journal of Jilin University(Medicine Edition)
2024;50(6):1751-1756
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota is a vast microbial ecosystem,specifically present in the organism and plays an important regulatory role in the body's health or disease state together with its metabolites.After spinal cord injury,the complex pathophysiology at the site of trauma makes axonal regeneration difficult,and the autonomic motor dysfunction induced by spinal cord injury disrupts gastrointestinal function and causes gut microbiota imbalance.The previous clinical outcomes of neurorepair strategies after spinal cord injury have not been ideal.The dysregulated gut microbiota and neuroinflammation after spinal cord injury are closely associated with the prognosis of the patients.The potential mechanisms by which the gut microbiota may influence the neuroinflammation after spinal cord injury may include the activation of gut-associated lymphoid tissue and disruption of the intestinal barrier by the imbalanced microbiota,and gut microbiota and its metabolites such as lipopolysaccharides(LPS),short chain fatty acids(SCFAs),5-hydroxytryptamine(5-HT),and tryptophan,as well as immune cells,inflammatory factors,and neurotransmitters the local inflammatory response in the spinal cord through the circulatory system.This paper revews the studies on the changes in gut microbiota after spinal cord injury and their effects on the spinal cord neuroinflammation,providing new targets and new ideas for improving the neuroinflammation after spinal cord injury.
