Association analysis on peripheral blood lymphocyte subsets and occurrence of carotid atherosclerosis
10.13481/j.1671-587X.20240525
- VernacularTitle:外周血淋巴细胞亚群与颈动脉粥样硬化发生的关联性分析
- Author:
Jiayuan YU
1
;
Di ZHAO
;
Xin JIANG
;
Jing XU
;
Lili JIANG
;
Hongyu JIANG
Author Information
1. 吉林大学第一医院体检中心,吉林长春 130021
- Keywords:
Atherosclerosis;
Carotid atherosclerosis;
Risk factor;
Natural killer cell;
Low density lipoprotein cholesterol
- From:
Journal of Jilin University(Medicine Edition)
2024;50(5):1400-1405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between the peripheral blood lymphocyte subsets and the occurrence of carotid atherosclerosis(CAS)and discuss the risk factors of CAS,and to provide the basis for risk prediction and early intervention of CAS.Methods:A total of 419 subjects were selected according to the inclusion and exclusion criteria.All the subjects underwent carotid ultrasonography,and the detection of T lymphocyte,B lymphocyte,and natural killer(NK)cell subsets were performed.According to the carotid artery intima-media thickness(IMT),the subjects were divided into normal carotid artery group(n=166)and CAS group(n=253).The basic data and laboratory inspection indexes of the subjects in two groups were collected,including age,gender,blood pressure,medical history,smoking history,medication history,blood lipids,and percentages of T lymphocyte,B lymphocyte,and NK cell subsets.The risk factors for the occurrence of CAS of the subjects were analyzed using Logistic regression analysis.Results:The univariate analysis results showed that compared with normal carotid artery group,the age,morbidity rate of hypertension,morbidity rate of diabetes,and smoking rate of the subjects in CAS group were increased(P＜0.05),and the percentages of CD4+T lymphocytes,CD4+T lymphocyte count,CD4+/CD8+ratio,CD16+CD56+NK cell count,and low-density lipoprotein cholesterol(LDL-c)level in peripheral blood were increased(P＜0.05),while the percentage of CD8+T lymphocyte was decreased(P＜0.05).The multivariable Logistic regression analysis results showed that age(OR=1.112,95％CI:1.083-1.142,P＜0.001),smoking(OR=1.997,95％CI:1.192-3.346,P=0.009),LDL-c(OR=1.427,95％CI:1.017-2.001,P=0.039),and percentage of CD4+T lymphocyte(OR=1.044,95％CI:1.002-1.087,P=0.039)were the independent risk factors for the occurrence of CAS.Conclusion:The percentage of CD4+T lymphocyte is associated with the occurrence of CAS and it is a predictive risk factor for CAS.
