Influence of probiotics on gastrointestinal motility and hormone secretion of rats with severe brain injury
10.3760/cma.j.issn.1674-2907.2011.09.001
- VernacularTitle:益生菌对重型颅脑损伤大鼠胃肠动力及胃肠激素分泌的影响
- Author:
Min ZHOU
1
;
Hua-Hua YIN
;
Jing-Ci ZHU
Author Information
1. 第三军医大学
- Keywords:
Severe brain injury;
Probiotics;
Enteral nutrition;
Gastrointestinal motility;
Gastrointestinal hormone
- From:
Chinese Journal of Modern Nursing
2011;17(9):993-996
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of probiotics on gastrointestinal motility and hormone secretion of rats with severe brain injury. Methods Severe brain injury rats were prepared. 54 Sprague-Dawley rats were randomized into three groups: group A ( sham-operation), group B ( standard enteral nutrition) and group C (standard enteral nutrition plus probiotics). Each group was equally divided into three subgroups on 1 d, 3d, 7 d, respectively. Gastric emptying rate, intestinal transmission rate, motilin ( MTL) and calcitonin gene related protein (CGRP) level in plasma were measured 1 d, 3 d, 7 d post trauma. Results Compared with group A, gastric emptying rate and intestinal transmission rate decreased significantly on 1 d post trauma(P <0. 01). They were still much lower in group B on 3 d post trauma(P < 0. 01), while they increased significantly in group C on 3 d post trauma(P <0.05). MTL and CGRP level in plasma increased significantly after severe brain injury; however, the levels in group B were much higher than those in group C on 1 d and 3d(P<0.01). There was no significant difference among the three groups regarding gastric emptying rate, intestinal transmission rate, and MTL and CGRP level. Conclusions Severe brain injury could induce disorder of gastrointestinal motility and dysfunction of hormone level. Early enteral nutrition supplemented with probiotics could improve gastrointestinal motility and transmission and regulate highly increased gastrointestinal hormone after severe brain injury.
