Effect of MEIS1 expression on survival in patients after radical gastrectomy and its value in prognostic evaluation
10.13481/j.1671-587X.20240520
- VernacularTitle:MEIS1表达对胃癌根治术后患者生存期的影响及其在预后评估中的价值
- Author:
Jiaxin YI
1
;
Yangyu ZHANG
;
Yingli FU
;
Yuchen PAN
;
Yongjie HAN
;
Jing JIANG
;
Yanhua WU
Author Information
1. 吉林大学第一医院临床流行病学研究室,吉林长春 130021
- Keywords:
Myeloid ecotropic viral integration site 1;
Gastric cancer;
Prognosis;
Biomarker;
Radical gastrectomy
- From:
Journal of Jilin University(Medicine Edition)
2024;50(5):1358-1364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the postoperative survival of the gastric cancer patients with different expression levels of myeloid ecotropic viral integration site 1(MEIS1),and to analyze the predictive value of MEIS1 expression in the prognosis evaluation of gastric cancer.Methods:In a gastric cancer survival cohort,215 patients who underwent radical gastrectomy were selected.Immunohistochemical staining was used to detect the expression levels of MEIS1 in both gastric cancer and adjacent normal tissues.The relationship between expression level of MEIS1 and the clinicopathological characteristics of the patients were analyzed by x2 test or Fisher's exact probability method;survival curves were plotted by Kaplan-Meier method;the differences in survival of the patients between MEIS1 high expression group and MEIS1 low expression group were compared by Log-rank test;multivariate Cox proportional hazards regression model was used to calculate the hazard ratios(HR)and 95％confidence intervals(CI)to assess the relationship between MEIS1 expression level and the survival of the gastric cancer patients.Results:The immunohistochemical staining result showed that the expression level of MEIS1 in gastric cancer tissue was decreased.The univariate analysis results showed that the patients with high MEIS1 expression had a longer overall survival than those with low expression(P=0.049),and had a better prognosis.The multivariate Cox proprotional hazards regression analysis results showed that the low MEIS1 expression and high TNM stage were the independent risk factors for poor prognosis of the patients with gastric cancer(HR=1.577,95％CI:1.011-2.460,P=0.045;HR=2.709,95％CI:1.708-4.297,P＜0.001).Conclusion:The gastric cancer patients with low expression of ME1S1 have a shorter postoperative overall survival;MEIS1 is a promising biomarker for prognosis assessment of the patients after radical gastrectomy.
