Research progress in effect of intestinal flora on occurrence and development of breast cancer and its therapeutic application
10.13481/j.1671-587X.202404035
- VernacularTitle:肠道菌群对乳腺癌发生发展的影响及其治疗应用的研究进展
- Author:
Xiaomin FU
1
;
Jianling JIA
;
Yanhong DOU
;
Wenyong REN
;
Aiping SHI
Author Information
1. 吉林大学第一医院乳腺外科,吉林长春 130021
- Keywords:
Breast neoplasm;
Gut microbiota;
Estrogen metabolism;
Immunoregulation
- From:
Journal of Jilin University(Medicine Edition)
2024;50(4):1182-1188
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of breast cancer is increasing year by year,and its pathogenesis is highly complex.The dysregulation of gut microbiota function is closely related to the occurrence and development of breast cancer.The estrogen levels through enterohepatic circulation is regulated by β-glucuronidase produced by the gut microbiota,thereby influencing the occurrence and development of hormone receptor-positive breast cancer and leading to tamoxifen resistance.The metabolites from the gut microbiota,such as short-chain fatty acids(SCFAs)and lithocholic acid(LCA),can participate in regulating the tumor cell cycles and cell proliferation.The colonization of gut microbiota maintains the integrity of the intestinal barrier and regulates the anti-tumor immunity mediated by T lymphocytes.Maintaining gut microbiota homeostasis can enhance the efficacy of tumor chemotherapy and immunotherapy and reduce the adverse reactions in anti-tumor treatments.The targeted action of engineered probiotics in immunotherapy can improve the precision of drug treatment.The effect of gut microbiota on radiotherapy is not yet clear,but regulating gut microbiota can aid in the treatment of radiation enteritis.This review discusses the correlation and effect of gut microbiota on breast cancer and analyzes its role in the treatment of breast cancer.
