Research progress in biological function of chitooligosaccharide and its application in biomedical field

VernacularTitle:壳寡糖的生物学功能及其在生物医学领域中应用的研究进展
Author: Shaoru WANG ¹ ; Yungang LUO
Author Information

1. 吉林大学口腔医院修复科,吉林长春 130021
Keywords: Chitooligosaccharide; Chitosan; Biological function; Biomedical application; Tissue regeneration
From: Journal of Jilin University(Medicine Edition) 2024;50(4):1164-1172
CountryChina
Language:Chinese
Abstract: Chitooligosaccharides(COS),as the degradation products of the natural polysaccharide chitosan(CS),retain the good biocompatibility,non-toxicity,and biodegradability of CS.Additionally,due to the shortened sugar chains and reduced molecular weight,their water solubility and bioactivity are improved,making them more easily absorbed and utilized by organisms.In recent years,COS has received increasing attention.While there are numerous studies on the biological functions of CS and its applications in the biomedical field,the research on the functions and applications of COS is relatively limited.This study summarizes and analyzes the main biological functions of COS(anti-inflammatory,anti-tumor,antibacterial,and tissue regeneration promotion)and their possible mechanisms.It also discusses the research progress in the applications of COS in the biomedical field,in order to provide the theoretical basis and reference for the further research and broader application of COS in biomedicine.