An SD rats animal model for pressure ulcer study
10.3760/cma.j.issn.1674-2907.2010.36.006
- VernacularTitle:压疮护理SD大鼠模型的建立
- Author:
Jia-Yuan ZHUANG
1
;
Ji-Hong SONG
;
Xiao-Ying JIANG
;
Pin-Cang XIA
;
Jun-Jian YE
;
Li-Xuan WANG
Author Information
1. 350108,福州,福建医科大学护理学院
- Keywords:
Pressure ulcers;
Turn over;
Nursing;
Animal model;
Rat
- From:
Chinese Journal of Modern Nursing
2010;16(36):4363-4365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an SD rats animal model for preventive nursing of pressure ulcer.Methods 30 healthy male SD rats were randomly and averagely divided into 6 groups, which were put in simple compression devices supinely after anesthesia, with their hind limb joints regarded as oppressed points.The pressure of each group was: 70, 64, 58, 53, 48 and 44mmHg, respectively. By observing skin color change after two hours of compression and then calculating LD50, the pressure that made half animals' compression skin red was obtained. Results No group had visible skin damages and other serious changes, but compression local skin redness was found. Under the experimental conditions, the pressure of the skin redness among half of the animals was 55.08 mmHg. Conclusions In this model, the most appropriate pressure was 55.08 mmHg. The SD rats pressure ulcer animal model is feasible and could be applied to animal studies on preventive nursing of pressure ulcer.
