Challenges and opportunities in liver cancer immunotherapy
10.19405/j.cnki.issn1000-1492.2024.08.001
- VernacularTitle:肝癌免疫治疗的挑战与机遇
- Author:
Beicheng SUN
1
Author Information
1. 安徽医科大学第一附属医院肝胆胰及移植外科,合肥 230022
- Keywords:
liver cancer;
immune microenvironment;
biomarkers;
immunotherapy
- From:
Acta Universitatis Medicinalis Anhui
2024;59(8):1295-1301
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer is the sixth most common type of cancer worldwide and the third leading cause of cancer-related deaths.Approximately 30％of patients are diagnosed at an early stage of liver cancer,at which point cura-tive treatments such as partial liver resection and liver transplantation can be performed,leading to a median overall survival exceeding 60 months.However,most patients are diagnosed at an advanced stage of liver cancer,where treatment options often include targeted therapies and immune checkpoint inhibitors.Systemic treatments including immune checkpoint inhibitors play a crucial role in significantly improving the prognosis of patients with advanced liver cancer.Therefore,in-depth exploration of the immune microenvironment characteristics of liver cancer and ac-tive identification of biomarkers for immunotherapy are crucial to advancing and improving immunotherapy for liver cancer.
