An Analysis of the Metabolic Syndrome and the Clinicopathologic Prognostic Factors Affecting Survival in Patients with Uterine Endometrial Cancer.
- Author:
Byung Hwa JEON
1
;
Sang Wook YI
;
Jung Won PARK
;
Han Moie PARK
;
Sang Soo LEE
;
Woo Seok SOHN
Author Information
1. Department of Obstetrics and Gynecology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Korea. bigmoie@gnah.co.kr
- Publication Type:Original Article
- Keywords:
Endometrial cancer;
Metabolic syndrome;
Metastatic ratio;
5-year survival
- MeSH:
Body Mass Index;
Endometrial Neoplasms*;
Female;
Humans;
Hypertension;
Insulin;
Insulin Resistance;
Lymph Nodes;
Neoplasm Metastasis;
Survival Rate;
Triglycerides
- From:Korean Journal of Obstetrics and Gynecology
2006;49(4):847-857
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We aimed to evaluate the metabolic syndrome and the clinicopathologic prognostic factors of endometrial cancer results from 35 surgically staged patients and to find out those novel prognostic factors. METHODS: This study is based on 35 endometrial cancer patients. Difference of survival rate in the following histologic parameters and parameter of metabolic syndrome was analyzed: age, body mass index (BMI), hypertension, insulin resistance, triglyceride, HDL-cholesterol, FIGO stage, tumor grade, myometrial invasion, cervical involvement, adnexal metastasis, and lympho-vascular space invasion (LVSI). Concerning lymph node involvement, the ratio of metastatic lymph node to dissected lymph node (metastatic ratio: MR) was calculated in total pelvic lymph node. MR was divided into less than 0.5 to more than 0.5. In each group, 5-year survival rate (5YSR) was analyzed and compared. RESULTS: The overall 5YSR for all 35 patients was 78.8%. The 5YSR for insulin resistance and normal insulin tolerance were 94.1%, 33.6% (p=0.009). LVSI, adnexal metastasis and MR of pelvic lymph node were independent prognostic factors for the endometrial cancer patients. CONCLUSION: Our results suggested that there was a relationship between insulin resistance and endometrial cancer and we confirmed the need for the treatment of metabolic disturbance and the prevention of metabolic syndrome aimed at correcting hormonal-metabolic disturbance in endometrial cancer patients. The MR of pelvic lymph node is thought that one of the most important prognostic factor of the endometrial cancer.
