A Pilot Randomized Clinical Study of the Additive Treatment Effect of Photodynamic Therapy in Breast Cancer Patients with Chest Wall Recurrence.
10.4048/jbc.2014.17.2.161
- Author:
Yan LIU
1
;
Guofang HOU
;
Xiaobei ZHANG
;
Jing Jing LIU
;
Sheng ZHANG
;
Jin ZHANG
Author Information
1. 3rd Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China. jzhangtjmu@gmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Breast neoplasms;
Photochemotherapy;
Recurrence;
Thoracic wal
- MeSH:
Breast Neoplasms*;
Humans;
Photochemotherapy*;
Prospective Studies;
Radiotherapy;
Recurrence*;
Thoracic Wall*
- From:Journal of Breast Cancer
2014;17(2):161-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study investigated the additive effect of photodynamic therapy (PDT) plus traditional radiotherapy (RT) for patients with breast cancer and chest wall recurrence. METHODS: A total of 40 patients with recurrent breast cancer were prospectively randomized to receive RT alone (group A, n=20) or PDT and RT in combination (group B, n=20). Traditional RT at a dose of 50 Gy was delivered in 25 fractions with or without exposure to 5-aminolevulinic acid and red light as PDT. RESULTS: The response rates were not statistically different between the groups, but more patients achieved a complete response (CR) in group B (50%) than in group A (20%). The median time to CR in group B was significantly shorter than that in group A (109.6 days vs. 175.2 days, p=0.001). Adverse event profiles were not different between the groups. CONCLUSION: An additive antitumor effect is demonstrated with additional PDT to RT. This combination therapy might reduce the duration of exposure to RT, but further investigation is warranted.
