Hematologic and hemodynamic findings during hemodialysis in 13 beagle dogs.
- Author:
Chang Moo JI
1
;
Hae Won JUNG
;
Hyo Mi JANG
;
Jong Hyun MOON
;
Dong In JUNG
Author Information
1. Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea. jungdi@gnu.ac.kr
- Publication Type:Original Article
- Keywords:
hemodialysis;
renal failure;
dog
- MeSH:
Amylases;
Anemia;
Animals;
Blood Cell Count;
Blood Pressure;
Blood Urea Nitrogen;
Calcium;
Chemistry;
Creatinine;
Dogs*;
Hemodynamics*;
Hemorrhage;
Humans;
Hypotension;
Leukocytes;
Leukopenia;
Phosphorus;
Potassium;
Renal Dialysis*;
Renal Insufficiency;
Thrombocytopenia
- From:Journal of Biomedical Research
2014;15(2):58-61
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hemodialysis is an effective therapy for renal failure in veterinary practice. To evaluate hematologic and hemodynamic changes during hemodialysis, 13 dogs were treated with hemodialysis, after which complete blood cell counts (CBC), serum chemistry, and mean systolic blood pressure were analyzed. For CBC, white blood cells (WBC) and platelets underwent significant changes. In serum chemistry, there were significant differences in blood urea nitrogen (BUN), creatinine, total protein, albumin, globulin, amylase, calcium, potassium, and phosphorus contents. Further, mean systolic blood pressure suddenly increased in early hemodialysis and decreased significantly thereafter. During hemodialysis, adverse effects were observed in some dogs as follows: bleeding (1 dog), anemia (2 dogs), leukopenia (8 dogs), thrombocytopenia (2 dogs), and hypotension (1 dog). This study demonstrates hematologic and hemodynamic effects during hemodialysis as well as complications similar to human medicine. Before applying the commercialized human hemodialysis system to canine renal failure patients, we monitored hematologic and hemodynamic findings during hemodialysis in healthy beagle dogs.
