Effect of combination therapy of methylprednisolone and cyclophosphamide on heart function and nursing in patients with refractory nephritic syndrome
10.3760/cma.j.issn.1674-2907.2008.33.007
- VernacularTitle:甲基强的松龙联合环磷酰胺冲击治疗难治性肾病对心功能的影响与护理
- Author:
Ai-Hua QI
1
;
Hong ZHANG
;
Rong CAO
Author Information
1. 陕西省西安市儿童医院
- Keywords:
Methylprednisolon;
Cyclophosphamide;
Refractory nephrotic syndrome;
Heart funetion monitoring: Children: Nursing
- From:
Chinese Journal of Modern Nursing
2008;14(33):3459-3462
- CountryChina
- Language:Chinese
-
Abstract:
0bjective To evaluate the heart function of patients with refractory nephmtic syndrome during a combination therapy of methylprednisolone(MP)and cyclophosphamide(CTX).Methods From January 2004 to December 2007.30 patients with refractory nephrotic syndrome.who were in hospital and received a combination therapy of MP and CTX.were recorded for their heart rate and blood pressure before and during treatment,as well as observed for the complications.ResulIs Comparing with those before treatment.patients' heart rates were much quickly and their blood pressure were remarkablv higher during the combination treatment. And there was a statistic siglnificance(P<0.05).When patients received MP treatment.complications.such as cardiopalmus and dizziness,proned to emerging in the third cycle.When they received CTX treatment, complications,just like sicchasia,vomit and cardiopalmus.appeared in the first cycle.In addition. Myelosuppression and lesion of liver function often occurred during the sequence therapy.Conclusions When patients received a combination therapy of MP and CTX,we should monitor their heart funcion SO as to promptly make propotional measure and prevent complications according to variation of heart rate and blood pressure.
