Amiodarone-induced Acute Respiratory Distress Syndrome Developed after Increasing Dosage of Amiodarone.
- Author:
Ki Jong OH
1
;
Changhwan KIM
;
Dae Gil KANG
;
Myung Soo PARK
;
Jong Seop SIM
;
Yong Bum PARK
Author Information
1. Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea. masque@hallym.or.kr
- Publication Type:Case Report
- Keywords:
Amiodarone;
Toxicity;
Adult respiratory distress syndrome
- MeSH:
Amiodarone;
Angiography;
Arrhythmias, Cardiac;
Eye;
Gastrointestinal Tract;
Incidence;
Liver;
Lung;
Oxygen;
Prevalence;
Respiratory Distress Syndrome, Adult;
Risk Factors;
Skin;
Thyroid Gland
- From:Soonchunhyang Medical Science
2012;18(2):155-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amiodarone is a highly effective antiarrhythmic agent. It is commonly used to treat ventricular and supraventricular arrhythmias. However, amiodarone has been found to be associated with a variety of adverse effects. Amiodarone causes toxicity to organs such as lung, gastrointestinal tract, liver, eye, thyroid gland, skin, and neuromuscular system. Among these side effects, pulmonary toxicity is one of the most serious ones. The prevalence of amiodarone-induced pulmonary toxicity is not known precisely, but recent studies have reported that incidence rates range from 1% to 13%. The risk factors associated with the development of pulmonary toxicity are age, duration of treatment, cumulative dosage, history of cardiothoracic surgery, and use of high oxygen mixture. Amiodarone use has been rarely related to development of acute respiratory distress syndrome (ARDS), which is often in association with surgery or pulmonary angiography. We experienced a case of amiodarone-induced ARDS which developed after an increase of amiodarone dosage.
