Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma
10.1097/CM9.0000000000003152
- VernacularTitle:Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma
- Author:
Chengji WANG
1
;
Liang WANG
Author Information
1. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
- Keywords:
Natural killer/T cell lymphoma;
Epstein–Barr virus;
Chemotherapy resistance;
Asparaginase;
Immunotherapy
- From:
Chinese Medical Journal
2024;137(19):2308-2324
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer/T cell lymphoma (NKTCL) is a malignant tumor originating from NK or T cells, characterized by its highly aggressive and heterogeneous nature. NKTCL is predominantly associated with Epstein–Barr virus infection, disproportionately affecting Asian and Latin American populations. Owing to the application of asparaginase and immunotherapy, clinical outcomes have improved significantly. However, for patients in whom first-line treatment fails, the prognosis is exceedingly poor. Overexpression of multidrug resistance genes, abnormal signaling pathways, epigenetic modifications and active Epstein–Barr virus infection may be responsible for resistance. This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.
