Regulation of fatty acid synthase on tumor and progress in the development of related therapies

VernacularTitle:Regulation of fatty acid synthase on tumor and progress in the development of related therapies
Author: Rilan BAI ¹ ; Jiuwei CUI
Author Information

1. Cancer Center, the First Hospital of Jilin University, Changchun, Jilin 130021, China
Keywords: Neoplasm; Fatty acid synthase; Fatty acid synthase inhibitor; Immune regulation
From: Chinese Medical Journal 2024;137(16):1894-1902
CountryChina
Language:Chinese
Abstract: Fatty acid synthase (FASN) is an essential molecule in lipid metabolic pathways, which are crucial for cancer-related studies. Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration, which are closely related to tumor occurrence and development, immune escape, and immune response. FASN-targeting antitumor treatment strategies are being developed. Therefore, in this review, we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related antitumor therapy development.