Molecular and therapeutic landscape of ferroptosis in skin diseases
10.1097/CM9.0000000000003164
- VernacularTitle:Molecular and therapeutic landscape of ferroptosis in skin diseases
- Author:
Jiayuan LE
1
;
Yu MENG
;
Ying WANG
;
Daishi LI
;
Furong ZENG
;
Yixiao XIONG
;
Xiang CHEN
;
Guangtong DENG
Author Information
1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
- Keywords:
Ferroptosis;
Skin diseases;
Regulated cell death;
Homeostasis;
Melanoma;
Psoriasis;
Systemic lupus erythematosus;
Vitiligo
- From:
Chinese Medical Journal
2024;137(15):1777-1789
- CountryChina
- Language:Chinese
-
Abstract:
Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.
