Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target
10.1097/CM9.0000000000003197
- VernacularTitle:Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target
- Author:
Yuxi FAN
1
;
Ye XU
;
Zhi HUO
;
Hedong ZHANG
;
Longkai PENG
;
Xin JIANG
;
W. Angus THOMSON
;
Helong DAI
Author Information
1. Department of Immunology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China
- Keywords:
TREM-1;
Kidney diseases;
Inflammatory response;
Biomarker;
Therapeutic targets
- From:
Chinese Medical Journal
2024;137(14):1663-1673
- CountryChina
- Language:Chinese
-
Abstract:
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival. TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders. More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases. There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease. This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury, renal fibrosis, diabetic nephropathy, immune nephropathy, and renal cell carcinoma.
