Histologic Diagnosis of Cervcial Precursor Lesion: Applying the Bethesda System and HPV 16, 18 Correlates.
- Author:
Jong LEE
1
;
Mi Sook KIM
;
Chi Dong HAN
;
Jeong Ja PARK
;
Jae Bok PARK
;
Tae Sung LEE
Author Information
1. Department of Obstetrics and Gnecology, College of Medicine, Catholic University of Daegu.
- Publication Type:Original Article
- Keywords:
Cervix;
Human papillomavirus;
PCR;
The Bethesda System
- MeSH:
Biopsy;
Cervix Uteri;
Classification;
Diagnosis*;
DNA;
DNA Viruses;
Female;
Human papillomavirus 16*;
Humans;
Papilloma;
Paraffin;
Polymerase Chain Reaction
- From:Korean Journal of Obstetrics and Gynecology
2001;44(6):1056-1061
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECT: To support the application of the Bethesda classification to the histologic diagnosis of cervical squamous lesions. METHODS: We evaluated the cervical biopsies and human papilloma virus (HPV) DNA status of 100 clinic patients. The 100 biopsy specimens were analyzed using criteria of the Bethesda system for low-grade squamous intraepithelial lesion(LSIL) and high-grade squamous intraepithelial lesions(HSIL) in association with analysis of HPV DNA virus type by PCR. RESULTS: By PCR amplified from paraffin embedded tissues, the 40 of 90 cases of classified as HSIL were HPV 16 or 18 positive and 1/10 cases of classified as LSIL was HPV 16 positive. CONCLUSION: This study supports the usefullness of certain histologic criteria of the Bethesda system for distinguishing squamous intraepithelial lesions into two grades.
