Hematopoietic aging: Cellular, molecular, and related mechanisms
10.1097/CM9.0000000000002871
- VernacularTitle:Hematopoietic aging: Cellular, molecular, and related mechanisms
- Author:
Li YE
1
;
Chuan TIAN
;
Ye LI
;
Hang PAN
;
Jinxiu HU
;
Liping SHU
;
Xinghua PAN
Author Information
1. The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Kunming Key Laboratory of Stem Cell and Regenerative Medicine, Basic Medical Laboratory, 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan 650032, China
- Keywords:
Stem cells;
Hematopoietic stem cell;
Niche;
Hematopoietic aging
- From:
Chinese Medical Journal
2024;137(11):1303-1312
- CountryChina
- Language:Chinese
-
Abstract:
Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow structure. Aging-related alterations in the inflammatory response, immunity, and stem cell niches are at the root of hematopoietic aging. Understanding the molecular mechanisms underlying hematopoietic and bone marrow aging can aid the clinical treatment of aging-related diseases. In particular, it is unknown how the niche reprograms hematopoietic stem cells (HSCs) in an age-dependent manner to maintain normal hematopoiesis in elderly individuals. Recently, specific inhibitors and blood exchange methods have been shown to reshape the hematopoietic niche and reverse hematopoietic aging. Here, we present the latest scientific discoveries related to hematopoietic aging and hematopoietic system rejuvenation, discuss the relationships between hematopoietic niche aging and HSC aging, and describe related studies on stem cell-mediated regulation of hematopoietic aging, aiming to provide new ideas for further study.
