Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
10.1097/CM9.0000000000003022
- VernacularTitle:Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
- Author:
Lu LI
1
;
Fei LIU
;
Chunyue FENG
;
Zhenjie CHEN
;
Nan ZHANG
;
Jianhua MAO
Author Information
1. Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang 310052, China
- Keywords:
Mitochondrial dysfunction;
Mitochondrial DNA;
cGAS-STING pathway;
Kidney diseases;
Chronic kidney disease
- From:
Chinese Medical Journal
2024;137(9):1044-1053
- CountryChina
- Language:Chinese
-
Abstract:
Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease. However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive. The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in many renal diseases. One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway. Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases. Furthermore, we summarize the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases. This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction.
