Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets
10.1097/CM9.0000000000003075
- VernacularTitle:Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets
- Author:
Wanlin YE
1
;
Kun HAN
;
Maodi XIE
;
Sheyu LI
;
Guo CHEN
;
Yanyan WANG
;
Tao LI
Author Information
1. Department of Anesthesiology, Laboratory of Mitochondria and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Keywords:
Mitochondria;
Mitochondrial energy metabolism;
Diabetic cardiomyopathies;
Physiology;
Physiological adaption;
Pathogenesis;
Therapeutics
- From:
Chinese Medical Journal
2024;137(8):936-948
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes, which could eventually develop heart failure and leads to the death of the patients. Although blood glucose control and medications to heart failure show beneficial effects on this disease, there is currently no specific treatment for diabetic cardiomyopathy. Over the past few decades, the pathophysiology of diabetic cardiomyopathy has been extensively studied, and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target. In this review, we summarize the latest research in the field of diabetic cardiomyopathy, focusing on mitochondrial damage and adaptation, altered energy substrates, and potential therapeutic targets. A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.
