Metabolic plasticity of T cell fate decision
10.1097/CM9.0000000000002989
- VernacularTitle:Metabolic plasticity of T cell fate decision
- Author:
Xiaoli PAN
1
,
2
;
Jiajia WANG
;
Lianjun ZHANG
;
Guideng LI
;
Bo HUANG
Author Information
1. National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Suzhou, Jiangsu 215123, China
- Keywords:
T cell immunotherapy;
T cell differentiation;
T cell exhaustion;
Metabolic reprogramming;
Tumor microenvironment
- From:
Chinese Medical Journal
2024;137(7):762-775
- CountryChina
- Language:Chinese
-
Abstract:
The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to the development of functional effectors or memory populations. However, within the tumor microenvironment (TME), metabolic stress impairs CD8 + T cell anti-tumor immunity, resulting in exhausted differentiation. Recent studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell immunotherapy. In this review, we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory conditions. Furthermore, we delved into the different metabolic switches that occur during T cell exhaustion, exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion, ultimately leading to a persistently exhausted state. Understanding the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer.
