Essential tremor-Parkinson's disease syndrome: clinical characteristics and subtypes using cluster analysis
10.1097/CM9.0000000000002229
- VernacularTitle:Essential tremor-Parkinson's disease syndrome: clinical characteristics and subtypes using cluster analysis
- Author:
Yanbing HOU
1
;
Qin HAN
;
Ruwei OU
;
Kuncheng LIU
;
Junyu LIN
;
Tianmi YANG
;
Huifang SHANG
Author Information
1. Department of neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
- Keywords:
Cluster analysis;
Essential tremor;
Parkinson’s disease;
Subtypes
- From:
Chinese Medical Journal
2023;136(4):446-450
- CountryChina
- Language:Chinese
-
Abstract:
Background::Essential tremor (ET) and Parkinson’s disease (PD) are common movement disorders. ET-PD syndrome is characterized by the occurrence of PD in patients with a previous history of ET, which may be an independent phenotype distinct from PD. This study aims to identify clinical characteristics and subtypes in ET-PD.Methods::A total of 93 newly diagnosed ET-PD patients and 93 newly diagnosed PD patients matched for age, sex, education, and disease duration of PD were selected using propensity score matching analysis. The K-means cluster analysis was performed for 11 variables derived from the ET-PD group, and cluster profiles were established through statistical analysis of demographic and clinical variables.Results::The ET-PD group consisted of a high number of patients with a family history of ET exhibiting evident tremor with milder hypokinesia and postural instability symptoms, as compared to the PD group. Through the cluster analysis, two clusters of ET-PD patients were identified. The ET-PD cluster 1 ( n = 34) had a shorter ET duration before PD onset, lower number of patients with a family history of ET, higher unified PD rating scale instability scores, higher non-motor symptoms scores (non-motor symptoms scale D1 scores, Hamilton depression scale scores, Hamilton anxiety scale scores, and PD sleep scale-2 scores), and higher Chinese version of the PD questionnaire-39 scores relative to the ET-PD cluster 2 ( n = 59). Conclusion::ET-PD patients had significantly different characteristics for motor symptoms as compared to PD patients, and may be distinctly divided into two clinical subtypes, namely, the ET-PD complex type and the ET-PD simple type.
