Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
10.1097/CM9.0000000000002158
- VernacularTitle:Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape
- Author:
Shengyuan DANG
1
,
2
;
Lili REN
;
Jianwei WANG
Author Information
1. National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences &
2. Peking Union Medical College, Beijing 100730, China
- Keywords:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);
Mutation;
Variants of concern;
Variants of interest;
Adaptive evolution
- From:
Chinese Medical Journal
2022;135(10):1213-1222
- CountryChina
- Language:Chinese
-
Abstract:
The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.
