Therapeutic developments in metabolic dysfunction-associated fatty liver disease
10.1097/CM9.0000000000002091
- VernacularTitle:Therapeutic developments in metabolic dysfunction-associated fatty liver disease
- Author:
Yiwen SHI
1
;
Jiangao FAN
Author Information
1. Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jlao Tong University School of Medicine, Shanghai 200092, China
- Keywords:
Metabolic dysfunction-associated fatty liver disease;
Nonalcoholic fatty liver disease;
Metabolic disorder;
Pharmacological targets;
Management
- From:
Chinese Medical Journal
2022;135(9):1009-1018
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become one of the most prevalent chronic liver diseases worldwide, bringing risk of multiorgan disfunctions including cardiovascular events, complications of cirrhosis, and even malignance. In terms of health burden management, screening patients with high risk of MAFLD and providing individual comprehensive treatment is critical. Although there are numerous agents entering clinical trials for MAFLD treatment every year, there is still no effective approved drug. The nomenclature of MAFLD highlighted the concomitant metabolic disorders and obesity. MAFLD patients with type 2 diabetes had higher risk of developing liver cirrhosis and cancer, and would benefit from anti-hyperglycemic agents; overweight and obese patients may benefit more from weight loss therapies; for patients with metabolic syndrome, individual comprehensive management is needed to reduce the risk of adverse outcomes. In this review, we introduced the current status and advances of the treatment of MAFLD based on weight loss, improving insulin resistance, and management of cardiometabolic disorders, in order to provide individualized therapy approaches for patients with MAFLD.
