Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis
10.1097/CM9.0000000000001612
- VernacularTitle:Elevated serum Dickkopf-1 is a biomarker for bone erosion in patients with psoriatic arthritis
- Author:
Chung YUKCHIU
1
;
Li ZHI-CHANG
;
Sun XIAO-LIN
;
Liu YAN-YING
;
Shao MIAO
;
Gan YU-ZHOU
;
Li YI-MIN
;
Li YU-HUI
;
Zhang XUE-WU
Author Information
1. Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135), Peking University People’s Hospital, Beijing 100044, China
- Keywords:
Dickkopf-1;
Psoriatic arthritis;
Bone erosion
- From:
Chinese Medical Journal
2021;134(21):2583-2588
- CountryChina
- Language:Chinese
-
Abstract:
Background::Psoriatic arthritis (PsA) is an inflammatory arthropathy characterized by psoriasis and bone erosion on radiology. Dickkopf-1 (Dkk-1) is considered to be the main inhibitor of the Wnt signaling pathway and results in reduced osteoblast proliferation. The aim of this study was to investigate the serum level of Dkk-1 and its association with bone erosion in PsA patients.Methods::Serum Dkk-1 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 69 patients with PsA and 60 controls, including 39 rheumatoid arthritis (RA) patients, and 21 healthy controls (HCs). Rheumatoid factor and anti-cyclic citrullinated peptide levels were also determined by ELISA. The association of Dkk-1 level with clinical and laboratory features of PsA was analyzed. Logistic regression analysis was used to analyze the risk factors for bone erosion in PsA.Results::Dkk-1 was elevated in 68.1% (47/69) of the patients with PsA, 46.2% (18/39) of RA patients, and 9.5% (2/21) of HCs. Serum Dkk-1 concentration was significantly higher in PsA patients compared with that in HCs. The level of serum Dkk-1 was correlated with a swollen joint count, and levels of complement components 3 and 4. Elevated Dkk-1 level (odds ratio = 4.440, 95% confidence interval: 1.246-15.817, P = 0.021) was identified as the risk factor for bone erosion in PsA. Conclusions::The serum level of Dkk-1 is abnormally elevated in PsA patients. The elevation of Dkk-1 might be involved in the mechanism of bone erosion in patients with PsA.
