T cell responses in respiratory viral infections and chronic obstructive pulmonary disease
10.1097/CM9.0000000000001388
- VernacularTitle:T cell responses in respiratory viral infections and chronic obstructive pulmonary disease
- Author:
Shouxiong HUANG
1
;
Quan HE
;
Linfu ZHOU
Author Information
1. Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Immunology Graduate Program, Cincinnati Children’s Hospital, Cincinnati, OH 45249, USA
- Keywords:
Chronic obstructive pulmonary disease;
Coronavirus disease 2019;
Inflammation;
Respiratory virus;
T cells
- From:
Chinese Medical Journal
2021;134(13):1522-1534
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease (COPD), resulting in significant health concerns and economic burdens. Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic, mild, to severe, depending on host immune cell responses to pathogens and interactions with airway epithelia. We critically review the activation, effector, and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD. Crosstalk among T cells, innate immune cells, and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD. We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4 + and CD8 + T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.
