Clinical utility of characterizing intestinal flora in septic kidney injury
10.1097/CM9.0000000000000724
- VernacularTitle:Clinical utility of characterizing intestinal flora in septic kidney injury
- Author:
Jiao-Jiao YUAN
1
;
Xue-Ni CHANG
;
Min LI
;
Qi-Xi YUAN
;
Xiao-Ling YANG
Author Information
1. Department of Critical Care, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China
- Keywords:
Intestinal flora;
Kidney injury;
Sepsis
- From:
Chinese Medical Journal
2020;133(7):842-846
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of septic acute kidney injury (AKI) is increasing, it has become a major threat to human health because of its acute onset, poor prognosis, and high hospital costs. The most common cause of AKI in critical-care units is sepsis. Septic AKI is a complex and multi-factorial process; its pathogenesis is not fully understood. In sepsis, the destruction of mucosal barriers, intestinal flora disorders, intestinal ischemia/reperfusion injury, use of antibiotics, and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host. Such changes further influence the occurrence and development of AKI. New technology is enabling various detection methods for intestinal flora. Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis, disease progression mechanism, and intestinal flora.
