Gut hormones in microbiota-gut-brain cross-talk
10.1097/CM9.0000000000000706
- VernacularTitle:Gut hormones in microbiota-gut-brain cross-talk
- Author:
Li-Juan SUN
1
,
2
;
Jing-Nan LI
;
Yong-Zhan NIE
Author Information
1. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China
2. Department of Clinical Nutrition, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China
- Keywords:
Microbiota;
Gut hormones;
Gut-brain axis;
Appetite;
Anxiety;
Depression
- From:
Chinese Medical Journal
2020;133(7):826-833
- CountryChina
- Language:Chinese
-
Abstract:
The homeostasis of the gut-brain axis has been shown to exert several effects on physiological and psychological health. The gut hormones released by enteroendocrine cells scattered throughout the gastrointestinal tract are important signaling molecules within the gut-brain axis. The interaction between gut microbiota and gut hormones has been greatly appreciated in gut-brain cross-talk. The microbiota plays an essential role in modulating many gut-brain axis-related diseases, ranging from gastrointestinal disorders to psychiatric diseases. Similarly, gut hormones also play pleiotropic and important roles in maintaining health, and are key signals involved in gut-brain axis. More importantly, gut microbiota can affect the release and functions of gut hormones. This review highlights the role of gut microbiota in the gut-brain axis and focuses on how microbiota-related gut hormones modulate various physiological functions. Future studies could target the microbiota-hormones-gut brain axis to develop novel therapeutics for different psychiatric and gastrointestinal disorders, such as obesity, anxiety, and depression.
