Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases
10.3760/cma.j.issn.0366-6999.20121475
- Author:
Hai-Tao LIU
1
;
Hai-Chang WANG
;
Ling TAO
;
Cheng-Xiang LI
;
Fei LI
;
Yu-Yang ZHANG
;
Bo-Wu LIU
Author Information
1. Department of Cardiology
- Keywords:
growth-differentiation factor 15;
biomarker,cardiovascular disease
- From:
Chinese Medical Journal
2013;(7):1350-1354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease.Data sources To identify relevant publications,we searched PubMED database combining the textual terms of heart,cardiac,cardiovascular disease with GDF-15.Study selection Well-controlled,relatively large-scale,retrospective studies as well as meaningful individual cases were all selected as materials.Results GDF-15 is a distant member of the transforming growth factor-β cytokine superfamily.In myocardium,GDF-15 is weakly expressed under physiological conditions.However,its expression level is increased in response to pathological stress.Growing evidence indicate that elevated levels of GDF-15 is a promising prognostic biomarker in cardiovascular diseases.Moreover,GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart suffering from ischemia and reperfusion insult.Conclusion Ve GDF-15 may be a promising biomarker for evaluation and management of patient with cardiovascular diseases,and have potential protective properties on myocardium.
