Role of co-expression of c-Myc, EZH2 and p27 in prognosis of prostate cancer patients after surgery
10.3760/cma.j.issn.0366-6999.20122477
- Author:
Ke LI
1
;
Ming-Kun CHEN
;
Jie SITU
;
Wen-Tao HUANG
;
Zu-Lan SU
;
Dan HE
;
Xin GAO
Author Information
1. Department of Urology
- Keywords:
prostate cancer;
prognosis;
p27;
c-Myc;
EZH2;
biochemical recurrence
- From:
Chinese Medical Journal
2013;(1):82-87
- CountryChina
- Language:Chinese
-
Abstract:
Background c-Myc,EZH2 and p27 were defined to modulate the behavior of prostate cancer with pro-tumoral or anti-tumoral effects and had ability in predicting prostate cancer progression,but the research of their co-expression value of prognosis is rarely.This study aimed to investigate the prognostic value of combining tri-marker together in patients with intermediate-risk prostate cancer after surgery.Methods Expression levels of c-Myc,EZH2 and p27 in 129 patients with intermediate-risk prostate cancer were assessed using immunohistochemistry in a semi-quantitative manner.The expression profiles of these three markers were analyzed and investigated for association with biochemical recurrence.Results In all,fifty of 129 cases experienced biochemical recurrence during a median follow-up time of 31 months (range,6-60 months).Of these relapse patients,one case without and 10 cases with any single positive marker were observed; 39 cases were detected with any two or all three positive markers (22 cases with any two and 17 cases with all three positive markers).Survival analysis showed that patients with over-expression of c-Myc or EZH2,and lower expression of p27 manifested significantly higher biochemical recurrence rates.Subsequent multivariate analysis revealed that c-Myc,EZH2 and p27 expression statuses showed potential in predicting relapse,respectively.Notably,combining three markers together as a "composite index" (0 or 1,vs.2 or 3 positive markers) provided powerful prognostic value (HR 6.57,95％ CI 3.02-14.31,P ＜0.001).There was a significant difference between the patient subgroups with 0 or 1 and those with 2 or 3 positive markers expression statuses,and tri-marker composite index was an independent risk factor for predicting relapse in patients with intermediate-risk prostate cancer after surgery.Conclusion Composite index of c-Myc,EZH2,and p27 can be valued as powerful prognosis parameter for intermediate-risk prostate cancer patients after the surgery,and postoperative adjuvant therapy can be adopted accordingly.
