JAK2 V617F positive essential thrombocythemia developing in a patient with CD5-chronic lymphocytic leukemia
10.3760/cma.j.issn.0366-6999.2012.11.044
- Author:
Ju WEI
1
;
Chun WANG
;
You-Wen QIN
;
Jun ZHU
;
Yang-Rong GAO
;
Qi CAI
;
Shi-Ke YAN
Author Information
1. Department of Hernatology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
- Keywords:
essential thrombocythemia;
chronic lymphocytic leukemia;
JAK2 V617F mutation;
CD5-;
fluorescence in situ hybridization
- From:
Chinese Medical Journal
2012;(11):2076-2079
- CountryChina
- Language:Chinese
-
Abstract:
Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia (ET) in a patient is extremely rare,with only 10 cases reported thus far in literature.This paper describes a 94-year-old male having atypical B-CLL with CD5- (CD5-) phenotype and ET.In this patient,we performed interphase fluorescence in situ hybridization (FISH) analysis which revealed 13q14.3 deletion in 31％ of B-lymphocyte nuclei and RB1 deletion in 27％ of B-lymphocyte nuclei,but not in neutrophils and T-lymphocytes.Furthermore,we identified JAK2 V617F mutation in the peripheral blood nucleated cells and neutrophils,but not in the B- and T-lymphocyte populations.Therefore,it was concluded that the occurrence of CD5- B-CLL and ET in this patient was pathogenically independent.
