A 6-year-old girl with vaginal spotting who was diagnosed with perivascular epithelioid cell neoplasm after vaginoscopic resection.
10.5468/ogs.2014.57.5.409
- Author:
Hyun Jung CHO
1
;
Mi Kyung LEE
;
Byung Moon KANG
;
Sung Hoon KIM
;
Hee Dong CHAE
;
Chung Hoon KIM
Author Information
1. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. bmkang@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Perivascular epithelioid cell neoplasms;
Resection;
Vagina;
Vaginoscopy
- MeSH:
Brain Neoplasms;
Child*;
Epithelioid Cells*;
Female;
Follow-Up Studies;
Humans;
Magnetic Resonance Imaging;
MART-1 Antigen;
Metrorrhagia*;
Organoids;
Perivascular Epithelioid Cell Neoplasms;
Recurrence;
S100 Proteins;
Vagina
- From:Obstetrics & Gynecology Science
2014;57(5):409-411
- CountryRepublic of Korea
- Language:English
-
Abstract:
Perivascular epithelioid cell neoplasm (PEComa) is a rare tumor with unknown malignant potential. We report a case of a 6-year-old child with history of brain tumor (pineoblastoma), who presented with intermittent vaginal spotting for 6 months. A vaginoscopy revealed a 1.5x1.0-cm mass on the vaginal wall. Pathological examination demonstrated that the tumor was composed of clear cells with organoid patterns, which were immunohistochemically positive for HMB-45 and TFE3, and negative for CK, HNF1-B, SOX10, Melan A, and S-100 protein. These findings were consistent with PEComa arising from the vagina. Regular follow-up with magnetic resonance imaging has shown no signs of recurrence. This case shows that early detection of PEComa and subsequent regular follow-ups are important because of the neoplasm's unknown malignant potential.