A Study on the T Lymphocyte Subsets and Serum IgE in Patients with Atopic Dermatitis.
- Author:
Seung Joo KANG
;
Seon Hoon KIM
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
T cell subsets;
IgE;
Monoclonal antibodies169
- MeSH:
Antibodies, Monoclonal;
Dermatitis, Atopic*;
Humans;
Immunoenzyme Techniques;
Immunoglobulin E*;
T-Lymphocyte Subsets*;
T-Lymphocytes
- From:Korean Journal of Dermatology
1987;25(2):169-175
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was undertaken to elucidate any quantitative abnormalities of Tlymphocyte subsets (helper/inducer T cell; T cell and suppressor/cytotoxic T cell: T cell) and IgE levels in the peripheraI blood in atopic dermatitis patients by using monoclonal antibodies and enzyme immunoassay, respectively. In addition we have tried to ascertain whether there are any correlations betveen such immuiiologic abnormalities and the severity of the disease. The results showed that there were significant decrease in the mean percentage of T Cells and increase in the mean value of T/T cell ratios in patients with atopic dermatitis. These changes seem to relate to the severity of the disease when evaluated as groups. A significant increase in the mean value of serum IgE was found in atopic dermatitis patients and the change was related to the severity of the disease. But increase of serum IgE level did not correlated closely with the T cell abnormalities in each patients.
