Clinical significance of examining IL-2R in peripheral blood lymphocytes of patients with gastric cancer
10.3760/j.issn:0366-6999.2001.12.022
- VernacularTitle:胃癌患者外周血淋巴细胞白介素2受体检测的临床意义
- Author:
Xianghui WANG
1
;
Shenhua XU
;
Guiquan LÜ
;
Jianguo FENG
;
Chihong ZHU
;
Xingming ZHOU
Author Information
1. 浙江省肿瘤研究所
- Keywords:
interleukin-2 receptor;
flow cytometry;
cancer,gastric;
lymphocyte
- From:
Chinese Medical Journal
2001;114(12):1320-1322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the clinical significance of membrane receptors of interleukin-2 (CD25) in peripheral blood lymphocytes (PBL) of patients with gastric cancer. Methods CD25 percentages in PBL from 110 patients with gastric cancer and 100 normal individuals were examined by flow cytometry. Results were analyzed clinically and pathologically. Results Mean CD25% in PBL from normal individuals and patients with gastric cancer were 17.24±5.33 and 22.47±6.82, respectively, and the difference was significant (P<0.01). Abnormally elevated CD25% in PBL from patients with gastric cancer were correlated with tumor site, macropathology type, tumor size, differentiation degree and clinical stage. Conclusion Measuring CD25% in PBL from gastric cancer patients before surgery may provide a reference for diagnosis, immune treatment and judging prognosis.
