The distribution and significance of renal infiltrating cells in patients with diffuse crescentic glomerulonephritis
10.3760/j.issn:0366-6999.2001.12.008
- VernacularTitle:肾组织浸润细胞在新月体肾炎患者中的分布特点及意义
- Author:
Zheng TANG
1
;
Yan WU
;
Weixin HU
;
Xiaodan YAO
;
Hong ZHOU
;
Huiping CHEN
;
Zhihong LIU
;
Leishi LI
Author Information
1. Jinling Hospital Nanjing University School of Medicine
- Keywords:
CD68+ cells;
PCNA+ cells * CD8+ cells;
crescentic glomerulonephritis
- From:
Chinese Medical Journal
2001;114(12):1267-1269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance and distribution of renal infiltrating cells, including monocytes (CD68+ cells), proliferative cell nuclear antigen positive cells (PCNA+ cells), CD4+ and CD8+ cells in diffuse crescent glomerulonephritis (DCGN). Methods Fifty-six patients with DCGN were studied, including 10 cases of anti-glomerular basement membrane (GBM)-type Ⅰ DCGN, 26 immune complex-type Ⅱ DCGN, and 20 cases of pauci-immune-type Ⅲ DCGN. Glomerular and interstitial infiltrates of CD68+ and PCNA+ cells, and interstitial infiltrates of CD4+ and CD8+ cells were detected by using four-layer PAP methods. Results There was a significant increase of renal infiltrating CD68+, PCNA+, CD4+ and CD8+ cells in patients with DCGN compared with that in normal controls. In patients with type Ⅰ DCGN, there was a higher number of renal infiltrating CD68+ and PCNA+ cells than that in patients with type Ⅱ and Ⅲ DCGN. A glomerular infiltrates of CD68+ and PCNA+ cells correlated with the interstitial infiltrates of CD4+ cells in type Ⅰ or Ⅲ DCGN patients. In lupus DCGN patients, the numbers of renal infiltrating CD68+ and PCNA+ cells were similar to vasculitis or type Ⅲ DCGN patients.Conclusion These findings demonstrate that the renal infiltrates of CD68+ and PCNA+ cells play an important role in patients with DCGN, that the infiltrates of CD4+ cells correlate with the infiltrates of CD68+ and PCNA+ cells may be an active marker of DCGN, and that cell-mediated immunity may contribute to crescent formation in lupus DCGN patients.
