Association of angiotensin Ⅱ type 1 receptor gene polymorphism with essential hypertension
10.3760/j.issn:0366-6999.2001.12.004
- VernacularTitle:血管紧张素Ⅱ受体1基因多态性与原发性高血压的相关性研究
- Author:
Zhenni JIANG
1
;
Feng YU
;
Geng XU
;
Wensheng ZHAO
Author Information
1. 浙江大学附属第二医院
- Keywords:
essential hypertension;
angiotensinⅡ;
receptor;
gene polymorphism
- From:
Chinese Medical Journal
2001;114(12):1249-1251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the polymorphism A1166C in the angiotensin Ⅱ type 1 receptor (AT1R) gene is associated with essential hypertension Methods A casecontrol study was carried out using 125 hypertensive and 103 normotensive subjects The AC variant at position 1166 (A1166C) of the AT 1R gene was identified by polymerase chain reaction (PCR) and PCR/restriction fragment length polymorphism (PCR/RFLP) analysis The digestion products were separated on 2% agarose gels and visualized with ethidium bromide under ultraviolet ray Results The differences in C1166 allele frequency and in the AC genotype distribution of the AT 1R gene between the hypertensive and normotensive groups were statistically significant (C allele: 0.092 vs 0.034, χ2=6.1.86,P<0.05; AC genotype: 0.184 vs 0.068, χ2=6.654,P<0.05) Conclusion The AC genotype is associated with essential hypertension, and the C allele may be a marker for predisposition to hypertension in Chinese Han population
